The Gynaecological Cancer Academy (GCA), which is run by ENGOT, sets itself the goal of nurturing and developing the next generation of leaders in gynaecological oncology in order to ensure continuity and the transfer of knowledge and experience among members of the clinical trial community.

The 8th GCA workshop took place in Baveno on September 30, 2016. CEEGOG was represented by two physicians, namely Dr. Jaroslav Klát (University Hospital in Ostrava) and Dr. Roman Kocián (General University Hospital in Prague).

The main topic of the workshop was Non-ovarian cancer. The most important presentations of the training module are webcasted and available on ESGO eAcademy.

OVARIAN Non-commercial trials
Trial Study description Status
ADRAPAC/
CEEGOG OX-03
documents available here
Symptomatic Ascites Drainage with a Patient-controlled Vascular Catheter
The target size of the group: 170 subjects
Ongoing
MITO33/
ENGOT-ov51
A Randomized phase III trial on Niraparib-TSR 042 vs physician’s choice chemotherapy in recurrent, ovarian, fallopian tube or primary peritoneal cancer patients not candidate for platinum retreatment
The target size of the group: 427 subjects
Ongoing
ENGOT-ov78/ SALVOVAR/GINECO A pragmatic randomized phase III trial to assess the utility of adjusting chemotherapy dose & dosing schedule with the SALVage weekly dose-dense regimen in patients with poor prognostic OVARian cancers based on the tumor unfavorable primary chemosensitivity and incomplete debulking surgery
The target size of the group: 715 subjects
Under preparation
GHOST/ENGOT A study evaluating the role of post surgery systemic therapy in upfront or relapsed setting in patients with aGCTs ​
The target size of the group: 150 subjects
Under preparation
LEPRE/MANGO Letrozole for Estrogen/Progesterone Receptor positive low-grade serous Epithelial ovarian cancer. A randomized phase III trial
The target size of the group: 132 subjects
Under preparation

Rare Cancers in Gynecologic Oncology/ENGOT Registry
A multi-center, retrospective and prospective observational study based on the collection of data related to patients with rare gynecological neoplasms Under preparation
AGO-OVAR 28/ENGOT-ov57 Niraparib vs Niraparib in combination with Bevacizumab in patients with carboplatinum-taxane based chemotherapy in advanced ovarian cancer (A multicentre randomised phase III trial)
The target size of the group: 970 subjects
Under preparation
ENGOT-ov62/ N-PLUS A Phase III randomized, open label study of NiraParib maintenance after Carboplatin and Paclitaxel in optimaLly debUlked advanced HRDpositive high-grade ovarian cancer patientSin first line therapy
The target size of the group: 640 subjects
Under preparation
ENGOT-ov74 /Swiss-GO-7/LoRiO Localized Radiotherapy with concurrent Olaparib in platinum-sensitive recurrent Ovarian cancer vs. standard of care: a randomised multicentre phase II trial (LoRiO)
The target size of the group: 90 subjects
Under preparation
HE4-FU-OVCA/
CEEGOG OX-01
documents available here
The Role of HE4 in the Follow-up of Advanced Ovarian, Fallopian Tube and Primary Peritoneal Cancer
A prospective multicentre observational study
The target size of the group: 150 subjects
Closed
ATALANTE/
ENGOT-ov29/GINECO
A randomized, double blinded, phase III study of Atezolizumab versus placebo in patients with late relapse of epithelial ovarian, fallopian tube, or peritoneal cancer treated by platinum-based chemotherapy and Bevacizumab
The target size of the group: 600 subjects
Closed
EXPRESSION VI/
ENGOT-ov40/NOGGO S13
Caroline meets HANNA – Holistic Analysis of longterm survivors with ovarian cancer
The target size of the group: 100-200 subjects per participating country
Closed
SOLERO/
ENGOT-OV64/NSGO-CTU
An Early Phase Randomized Trial of APX005M in BRCAwt Patients with Recurrent Ovarian Cancer
The target size of the group: 105 subjects
Preparation terminated

 

 

CERVICAL Non-commercial trials
Trial Study description Status
RECER/CEEGOG CX-07 Regression of severe cervical precancerous lesions and associated risk factors
The target size of the group: 300 subjects
Ongoing
RACE/
CEEGOG CX-06
documents available here
Rare cervical tumour study
The target size of the group: 300+ subjects
Ongoing
CERVANTES/
CEEGOG CX-05/
ENGOT-cx16
An international randomised trial of radical surgery followed by adjuvant (chemo)radiation versus no further treatment in patients with early-stage, intermediate-risk cervical cancer patients
The target size of the group: 514 subjects
Ongoing
PAROLA/ENGOT-cx18/GINECO PARa-aOrtic LymphAdenectomy in locally advanced cervical cancer
The target size of the group: 510 subjects
Under preparation
SENTICOL III/
ENGOT-cx4/GINECO
International validation study of sentinel node biopsy in early cervical cancer
The target size of the group: 950 subjects
Enrollment closed
COREPEX COmplications and REcurrence after Pelvic EXenteration: A retrospective multicenter cohort study. The target size of the group: 400 subjects Closed
SENTIX/
CEEGOG CX-01/
ENGOT-cx2
documents available here
Sentinel node in cervix cancer
A prospective observational trial on sentinel lymph node biopsy in patients with early stage cervical cancer
The target size of the SLN Study group: 600 subjects
The target size of the Control group: 100 subjects
Estimated enrollment period: 2016 – 2020
Closed
FERTISS/
CEEGOG CX-03/
ENGOT-cx14
documents available here
FERTIlity Sparing Surgery in cervical cancer patients outside controlled trials Closed
RSS-EAC-PAT/
CEEGOG CX-04
documents available here
The Risk Stratification System for endocervical adenocarcinoma based on tumor pattern and its clinical outcomes  Closed
ABRAX/
CEEGOG CX2/
ENGOT-cx3
documents available here
Oncological outcome after completing or abandoning (radical) hysterectomy in patients with cervical cancer and intraoperative detection of LN positivity Closed
CoNteSSa/NeoCon-F FIGO 2018 stage IB2(≥2cm ≤4cm) Cervical Cancer Treated with Neoadjuvant Chemotherapy Followed by Fertility Sparing Surgery (CoNteSSa)/ Neo-Adjuvant Chemotherapy and Conservative Surgery in Cervical Cancer to Preserve Fertility (NeoCon-F)
The target size of the group: 90 subjects
Preparation terminated

 

 

ENDOMETRIAL Non-commercial trials
Trial Study description Status
RAINBO MMRd-GREEN /ENGOT-en14/DGOG Refining Adjuvant treatment IN endometrial cancer Based On molecular features, TransPORTEC platform trials - MMRd-GREEN
An international, open-label, phase 3 trial that randomly assigns (1:1) patients to receive either adjuvant durvalumab in combination with and following radiotherapy, or standard adjuvant radiotherapy alonewith or without platinum-based chemotherapy.
The target size of the group: 316 subjects
Ongoing
EXPRESSION XI/
ENGOT-en16/NOGGO S22
IMPROVE -International Survey for Endometrial Cancer patients: perspective and expectation on therapy and quality of life(Expression XI)
The target size of the group: 200 subjects per participating country
Ongoing
RAINBO-p53abnRED/ENGOT-en14/GINECO Refining Adjuvant treatment IN endometrial cancer Based On molecular features, TransPORTEC platform trials – p53abn - RED
A randomized phase III trial testing maintenance olaparib versus observation after adjuvant chemoradiation for
p53abn endometrial cancer
The target size of the group: 526 subjects
Under preparation
STREAM-I/ENGOT-en22/ AGO Evaluation of preoperative clinical and translational selection criteria for cytoreductive surgery in endometrial cancer: A retrospective multicenter trial with an accompanying translational project
The target size of the group: 800 subjects
Under preparation
PORTEC-4a Randomised Phase III Trial of molecular profile-based versus
standard recommendations for adjuvant radiotherapy
for women with early stage endometrial cancer
The target size of the group: 450 subjects
Enrollment closed
ENGOT-EN2-DGCG/
EORTC 55102
A phase II Trial of postoperative chemotherapy or no further treatment for patients with node-negative stage I-II intermediate or high risk endometrial cancer
The target size of the group: 240 subjects
Enrollment closed
TESLA1/
CEEGOG EX-02
documents available here
Tracers for Endometrial cancer Sentinel node LAbelling
A Prospective observational study on sentinel node biopsy using two concurrent labelling techniques (radioactive tracer with/without blue dye vs. indocyanin green-ICG) in early-stage endometrial cancer patients
The target size of the group: 83 subjects
Closed
REGYS/CEEGOG EX-03
documents available here
Rare gynecological sarcoma study
The target size of the group: 782 subjects
Closed
SALVAGE/
CEEGOG EX01
documents available here
A retrospective trial on patients who have undergone salvage surgery for a recurrent uterine or cervical cancer
Salvage database – data from 620 patients collected
Closed

 

 

OVARIAN Commercial trials
Trial Study description Status
REJOICE/ENGOT-ov77/
GINECO
A Phase 2/3, Multicenter, Randomized Study of Raludotatug Deruxtecan (R-DXd), a CDH6-directed Antibody-drug Conjugate, in Subjects with Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancers
The target size of the group: 555 subjects
Ongoing
GLORIOSA/ENGOT-ov76/MITO A Randomized, multicenter, open-label, phase 3 study of mirvetuximab soravtansine in combination with bevacizumab versus bevacizumab alone as maintenance therapy for patients with FRα-positive recurrent platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal cancers who have not progressed after second-line platinum-based chemotherapy plus bevacizumab
The target size of the group: 418 subjects
Ongoing
REFRaME-O1/ENGOT-ov79/GEICO A Phase 2/3 Open-label Study Evaluating the Efficacy and Safety of Luveltamab Tazevibulin (STRO-002) versus Investigator’s Choice (IC) Chemotherapy in Women with Relapsed Platinum-resistant Epithelial Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) Expressing Folate Receptor Alpha (FOLR1)
The target size of the group: 600 subjects
Under preparation
EvoPAR‑Ovarian01/|ENGOT-ov82/GINECO A Phase III, Randomized, Double blind, Placebo-controlled, Multicenter, 3-cohort Study of Saruparib Second line Maintenance Therapy in Patients with Platinum Sensitive Relapsed Ovarian Cancer, with and without BRCAm who Progressed After First-line PARPi
The target size of the group: 570 subjects
Under preparation
ENGOT-ov83/ TORL123-002/NOGGO A Phase 2 Study Evaluating the Efficacy and Safety of TORL-1-23 in Women with Advanced Platinum-Resistant Epithelial Ovarian Cancer (Including Primary Peritoneal and Fallopian Tube Cancers) Expressing Claudin 6 (CLDN6)
The target size of the group: 180 subjects
Under preparation
RAINFOL-OV2/ENGOT-ov86/
AGO-A
A Phase 3 Randomized, Open-label Study of Rinatabart Sesutecan (Rina-S) versus Treatment of Investigator’s
Choice (IC) in Patients with Platinum Resistant Ovarian Cancer
The target size of the group: 530 subjects
Under preparation
DESTINY-OVARIAN-01/ENGOT-ov89/GEICO A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan with Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Therapy in HER2-Expressing Ovarian Cancer
The target size of the group: 562 subjects
Under preparation
EPIK-O/
ENGOT-ov61/GEICO
A Phase III, multi-center, randomized (1:1), open-label, active-controlled study to assess the efficacy and safety of alpelisib (BYL719) in combination with olaparib as compared to single agent cytotoxic chemotherapy, in participants with no germline BRCA mutation detected, platinum-resistant or refractory, high-grade serous ovarian cancer
The target size of the group: 358 subjects
Enrollment closed
BOUQUET/
ENGOT-GYN2/GINECO
A phase II, open-label, multicenter, platform study evaluating the efficacy and safety of biomarker-driven therapies in patients with persistent or recurrent rare epithelial ovarian tumors
The target size of the group: 80-200 subjects
Enrollment closed
ARTISTRY-7/
ENGOT-ov68/NOGGO
A Phase 3, Multicenter, Open-Label, Randomized Study of Nemvaleukin Alfa in Combination with Pembrolizumab Versus Investigator’s Choice Chemotherapy in Patients with Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
The target size of the group: 376 subjects
Enrollment closed
ROSELLA/
CORT125134-556/
ENGOT-ov72/MITO
A Phase III trial evaluating the efficacy of Relacoritant in combination with Nab-Paclitaxel in the treatment of advanced, platinum-resistant ovarian, fallopian tube or primary peritoneal cancer patients
The target size of the group: 360 subjects
Enrollment closed
MER-XMT-1536-1/
UPLIFT/
ENGOT-ov67/AGO-A
A Phase 1b/2, First-in-Human, Dose Escalation and Expansion Study of XMT-1536 In Patients with Solid Tumors Likely to Express NaPi2b
The target size of the group: 180 to 240 subjects
Enrollment closed
MIRASOL/
ENGOT-ov55/BGOG
A Randomized, Open-label, Phase 3 Study of Mirvetuximab Soravtansine vs. Investigator’s Choice of Chemotherapy in Advanced High-grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers with High Folate Receptor-Alpha Expression
The target size of the group: 430 subjects
Enrollment closed
MK-7339-001/
ENGOT-ov43/BGOG
A Randomized Phase 3, Double-Blind Study of Chemotherapy With or
Without Pembrolizumab Followed by Maintenance With Olaparib or Placebo for the First-Line Treatment of BRCA non-mutated Advanced Epithelial Ovarian Cancer (EOC)
The target size of the group: 1367 subjects
Enrollment closed
INNOVATE-3/
ENGOT-ov50/BGOG
Pivotal, randomized, open-label study of Tumor Treating Fields (TTFields, 200kHz) concomitant with weekly paclitaxel for the treatment of platinum-resistant ovarian cancer (PROC)
The target size of the group: 540 subjects
Enrollment closed
FIRST/
ENGOT-ov44/GINECO
A Patient‑centric, Randomized, Phase 3 comparison of Platinum‑based Therapy with or without bevacizumab to the same plus TSR‑042 as first‑line treatment of stage iii or iv non-mucinous ovarian cancer followed by maintenaNce therapy
The target size of the group: 720 - 960 subjects
Enrollment closed
ATHENA/
ENGOT-ov45/NCRI
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy
The target size of the group: 1000 subjects
Enrollment closed
IMAGYN050/
YO39523/GOG-3015/
ENGOT-ov39
A phase III, multicenter, randomized study of Atezolizumab versus placebo administered in combination with Paclitaxel, Carboplatin, and Bevacizumab for patients with newly-diagnosed stage III or stage IV ovarian, fallopian tube, or primary peritoneal cancer
The target size of the group: 1300 subjects
Enrollment closed
PRIMA/
ENGOT-ov26/GEICO/1509
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Studyof Niraparib Maintenance Treatment in Patients with HRD-Positive Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy
The target size of the group: 620 subjects
Enrollment closed
SOTIO/
SOV01
SOV01 A randomized, open-label, three-arm, multi-center Phase II clinical trial evaluating effect of addition of DCVAC/ OvCa to first line standard chemotherapy (carboplatin and paclitaxel) in women with newly diagnosed epithelial ovarian carcinoma
The target size of the group: additional 30 subjects
Closed
SOTIO/
SOV06
SOV06 An open-label, single-group, multicenter phase II clinical trial evaluating the effect of maintenance DCVAC/OvCa after standard of care therapy in women with first relapse of platinum-sensitive epithelial ovarian carcinoma
The target size of the group: 30 subjects
Closed
JAVELIN OVARIAN 200 A phase 3, multicenter, randomized, open-label study of Avelumab (MSB0010718C) alone or in combination with Pegylated liposomal Doxorubicin versus Pegylated Liposomal Doxorubicin alone in patients with platinum-resistant/refractory ovarian cancer
Approximately 550 patients will be randomized
Closed
SOTIO/
SOV02
SOV02 A randomized, open-label, parallel group, multi-center Phase II clinical trial evaluating effect of addition of DCVAC/ OvCa to standard chemotherapy (carboplatin and gemcitabine) in women with relapsed platinum sensitive epithelial ovarian carcinoma Closed
SOTIO/
SOV03
SOV03 A randomized, open-label, parallel group, multi-center Phase II clinical trial evaluating effect of addition of DCVAC/ OvCa to standard chemotherapy in women with relapsed platinum resistant epithelial ovarian carcinoma Closed
MILO/
ENGOT-ov11/BGOG
MEK Inhibitor in Low-grade Serous Ovarian Cancer
A Multinational, Randomized, Open-label Phase 3 Study of MEK162 vs. Physician’s Choice Chemotherapy in Patients with Recurrent or Persistent Low-grade Serous Carcinomas of the Ovary, Fallopian Tube or Primary Peritoneum
Closed
NOVA/
ENGOT-ov16/NSGO
Niraparib in OVArian cancer
A randomized, double-blind phase 3 trial of maintenance with niraparib vs placebo in patients with platinum-sensitive recurrent ovarian cancer
Closed
AVB500-OC-004/
ENGOT-ov66/GEICO
A Phase 3, Randomized, Double-Blind, Adaptive, Placebo/Paclitaxel-Controlled Study of AVB-S6-500 in Combination with Paclitaxel in Patients with Platinum-Resistant Recurrent Ovarian Cancer
The target size of the group: 300 to 500 subjects
Study early termination
ENGOT-ov73/LUPPA-1/GINECO A Randomized, Multicenter, Open-label, Phase III Study of Lurbinectedin in Combination with Paclitaxel vs. Platinum-based Chemotherapy or Weekly Paclitaxel as Treatment in Patients with Relapsed Ovarian Cancer
The target size of the group: 250 subjects
Preparation terminated
SOV09/VITALIA/
ENGOT-ov53/CEEGOG
A phase III, multicentre, randomized, double-blind, placebo-controlled trial of DCVAC/OvCa added to standard of care induction and maintenance therapy in patients with relapsed platinum-sensitive ovarian, fallopian tube, and primary peritoneal carcinoma
The target size of the group: 678 subjects
Preparation terminated

 

 

CERVICAL Commercial trials
Trial Study description Status
GCT1015-05/
ENGOT-cx8/BGOG
A Phase 2 Open-Label Trial of Tisotumab Vedotin (HuMax®-TF-ADC) alone or in Combination in First Line Recurrent or Stage IVB Cervical Cancer
The target size of the group: 140 subjects
Enrollment closed
KEYNOTE-A18/
ENGOT-cx11/MITO
A Randomized, Phase 3, Double-Blind Study of Chemoradiotherapy With or Without Pembrolizumab for the Treatment of High-risk, Locally Advanced Cervical Cancer
The target size of the group: 980 subjects
Enrollment closed
GCT1015-07/
ENGOT-cx12/BGOG
A Randomized, Open-Label, Phase 3 Trial of Tisotumab Vedotin versus Investigator’s Choice Chemotherapy in Second or Third Line Recurrent or Metastatic Cervical Cancer
The target size of the group: 486 subjects
Enrollment closed
GCT1015-04/
ENGOT-cx6/BGOG
A Single arm, Multicenter, Phase 2b Trial Investigating the Efficacy of Tisotumab Vedotin (HuMax®‑TF‑ADC) Therapy in Previously treated Patients with Recurrent or Metastatic Cervical Cancer
The target size of the group: 100 subjects
Enrollment closed
FERMATA/
ENGOTcx13/AGO
An International Randomized Double-blind Clinical Trial of BCD-100
Plus Platinum-based Chemotherapy with and without Bevacizumab versus Placebo Plus Platinum-based Chemotherapy with and without Bevacizumab as First-Line Treatment of Subjects with Advanced Cervical Cancer
The target size of the group: 316 subjects
Preparation terminated
BRAVA/
ENGOT-cx17/GINECO
A Phase 3 Trial of Balstilimab versus Investigator Choice Chemotherapy in Patients with Recurrent Cervical Cancer after Platinum-Based Chemotherapy
The target size of the group: 486 subjects
Preparation terminated

 

 

ENDOMETRIAL Commercial trials
Trial Study description Status
ENGOT-EN23/MK-2870-005/
MITO
A Phase 3, Randomized, Active-controlled, Open-label, Multicenter Study to Compare the Efficacy and Safety of MK-2870 Monotherapy Versus Treatment of Physician’s Choice in Participants With Endometrial Cancer Who Have Received Prior Platinum-based Chemotherapy and Immunotherapy
The target size of the group: 710 subjects
Ongoing
ENGOT-EN20/
GOG-3083/
XPORT-EC-042/BGOG
A Phase 3, Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial of Selinexor in Maintenance Therapy After Systemic Therapy for Patients With p53 WildType, Advanced or Recurrent Endometrial Carcinoma
The target size of the group: 220 subjects
Ongoing
ENGOT-EN26/MANGO A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan Versus Treatment of Physician’s Choice in Participants With Endometrial Cancer Who Have Received Prior Platinum-based Chemotherapy and Anti-PD-1/PD-L1 Immunotherapy
The target size of the group: 520 subjects
Under preparation
DESTINY/ENGOT-EN24/NSGO An Open label, Randomized, Multicenter, Controlled, Phase III Study of First-Line Trastuzumab Deruxtecan (T-DXd) Monotherapy versus Carboplatin and Paclitaxel with or without Pembrolizumab in Patients with HER2-expressing (IHC 3+/IHC 2+) Mismatch Repair Proficient (pMMR) Primary Advanced or Recurrent Endometrial Cancer
The target size of the group: 480 subjects
Under preparation
ENGOT-EN25/BNT323-01/NSGO A Phase III, randomized, multi-site, open-label trial of BNT323/DB-1303 versus investigator’s choice of chemotherapy in previously treated patients with HER2- expressing recurrent endometrial cancer
The target size of the group: 420 subjects
Under preparation
KEYNOTE-C93/
GOG-3064/
ENGOT-en15/MITO
A Phase 3 Randomized, Open-label, Active-comparator Controlled Clinical
Study of Pembrolizumab versus Platinum Doublet Chemotherapy in Participants With
Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma in the
First-line Setting
The target size of the group: 350 subjects
Enrollment closed
POD1UM-204/
INCMGA 0012-204/
ENGOT-EN12/NOGGO
An Umbrella Study of INCMGA00012 Alone and in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial CancerWho Have Progressed on or After Platinum-Based Chemotherapy (POD1UM-204)
The target size of the group: 300 subjects
Enrollment closed
RUBY/
ENGOT EN-6/NSGO
A Phase 3, Randomized, Double-blind, Multicenter Study of Dostarlimab (TSR-042) plus Carboplatin-paclitaxel versus Placebo plus Carboplatin-paclitaxel in Patients with Recurrent or Primary Advanced Endometrial Cancer (RUBY)
The target size of the group (PART I): 470 subjects
The target size of the group (PART II): 270 subjects
Enrollment closed
KEYNOTE-B21/ ENGOT-en11/BGOG A Phase 3, Randomized, Double-Blind Study of Pembrolizumab versus Placebo in Combination With Adjuvant Chemotherapy With or Without Radiotherapy for the Treatment of Newly Diagnosed High-Risk Endometrial Cancer After Surgery With Curative Intent
The target size of the group: 990 subjects
Enrollment closed
DUO-E/
ENGOT EN-10/BGOG
A Randomised, Multicentre, Double-blind, Placebo-controlled, Phase III Study of First-line Carboplatin and Paclitaxel in Combination with Durvalumab, Followed by Maintenance Durvalumabwith or without Olaparibin Patients with Newly Diagnosed Advanced or Recurrent Endometrial Cancer
The target size of the group: 699 subjects
Enrollment closed
SIENDO/
ENGOT-EN5/BGOG-EN5
A Randomized, Double-Blind, Phase 3 Trial of Maintenance with Selinexor/ Placebo After Combination Chemotherapy for Patients with Advanced or Recurrent Endometrial Cancer.
The target size of the group: 248 subjects
Enrollment closed
ENGOT-en21/KRT-232-118/AGO-A A Phase 2/3 Study of Navtemadlin as Maintenance Therapy in Subjects with TP53WT Advanced or Recurrent Endometrial Cancer Who Responded to Chemotherapy
The target size of the group: 268 subjects
Study early termination
ENGOT-en17/EQ132-303/GOG-3075/GINECO A Randomized, Double-Blinded, Placebo-Controlled Phase 3 Study of EQ132 (Lerociclib) with Letrozole, versus Placebo in Combination with Letrozole, in Participants with Advanced or Recurrent Grade 1 or 2 Endometrioid Endometrial Carcinoma
The target size of the group: 320 subjects
Preparation terminated

 

 

We would like to inform you that our Association  has endorsed the CEEGOG membership application of the Maribor center. We are pleased that CEEGOG has been expanding and currently includes centers from 4 countries - the Czech Republic, Slovakia, Poland and newly Slovenia.

It is our great pleasure to let you know that the protocol for the SENTIX trial (SENTinel lymph node in cervIX cancer) has been finished and the trial is now ready for new centers to join it and for new patients to be enrolled in.

SENTIX is a prospective observational international multicenter trial on sentinel lymph node biopsy in patients with early stage of cervical cancer. Our target is to enroll 300 patients and this could be achieved until the end of 2017.The trial chair is David Cibula, and the main investigator is Roman Kocian (General University Hospital in Prague, CZ). 

Since the SENTIX is the original CEEGOG trial it is our hope that the majority of CEEGOG centers will participate in it.

We are looking forward to our prospective mutual cooperation.  For futher information or if you have any queries, please do not hesitate to contact the CEEGOG office.

We would like to update you on the change of the CEEGOG residence. The proposal for the new place of residence was approved by all participants at the CEEGOG meeting in April 2016. Starting April 20, 2016, the Association resides in the city of Prague.

The GCA targets translational research, Phase 1/Phase 2 trials and Ph1 drugs development involving researchers and specialist in Ph1-2 clinical studies.

The 7th GCA workshop took place in Copenhagen on May 13 – 14, 2016. CEEGOG was represented by three physicians, Jaroslav Klát (University Hospital in Ostrava), Michal Zikán (General University Hospital in Prague) and Roman Kocián (General University Hospital in Prague).

During this creative meeting, which was supervised  by Prof. Ignace Vergote (Chair) and  Antonio Casado (Co-Chair) national network representatives presented phase 1, 2 trial proposals. Prof. Cristiana Sessa delivered a key note lecture focused on how Phase 1/2 should be carried on and how Phase 1 trials are being managed in Bellinzona Oncology Institute in Southern Switzerland. Dr. Mirza Mansoor (Dep. of Oncology, Copenhagen University Hospital) introduced a Ph 2 randomized Umbrella Trial in Recurrent Ovarian Cancer combining PD-L1 antagonist Durvalumab with an agent targeting immunosuppression in the tumor bed (AZD 5069, AZD 9150) as a complementary antitumor strategy. Later, individual proposals  were discussed and remarked. The  high importance of the annual meeting with ENGOT support was emphasised and  it was agreed to continue discussion via a teleconference in June 2016.

Should you need futher information, you are welcome to contact the CEEGOG office.

We are very pleased to announce that the trial on the role of HE4 in the follow-up of advanced ovarian, Fallopian tube and primary peritoneal cancer has been opened for the enrollment. Since the calculated size of the group is relatively small (150), we are conviced the enrollment will be complete within a relatively short time. We consider this trial to be a great opportunity for CEEGOG and some other centers.

The Principal investigators are Jiri Presl (UH Pilsen, CZ) and Vit Weinberger (UH Brno, CZ).

We are looking forward to cooperating with you and we really appreciate your support for this trial. For more information, please do not hesitate to contact CEEGOG office.

We would like to invite CEEGOG members and colleagues to the annual joint CEEGOG meeting, which is going to be held at the Diplomat Hotel Prague in Prague on Wednesday afternoon (17:00 pm – 22:00 pm) on 20th April 2016, one day before the IVW  (www.ivw-prague.cz). 

On 4th March, representatives of national trial groups had an appointment at the Sheraton Airport Hotel in Frankfurt. CEEGOG was represented by its chairman Prof. David Cibula and administrative manager Ivana Nohová. In addition to ongoing and new clinical trials, the Report from the ESGO council, the European Ovarian Cancer Consensus meeting (ESMO/ESGO) and New strategic goals, were discussed.

The ENGOT administrative meeting was held the day before. The main topics were as follows: Risk based monitoring, Trial budgeting and the ENGOT monitoring network. 

If you would like more information, please contact the CEEGOG admin office.

On 23rd October, a meeting of representatives of national trial groups was held at Acropolis Congress Center. CEEGOG was represented by its vice-chairman prof. Miloš Mlynček and administrative manager Taťána Růžičková. Ongoing clinical trials were discussed, as well as non trial activities . In addition to clinical trials, the  main topics were : ENGOT elections 2016-2020, the Report from the ESGO council, the European Ovarian Cancer Consensus meeting(ESMO/ESGO/ESTRO/and ENGOT strategic goals. For more information, please contact the CEEGOG admin office. 

The 19th Biannual Meeting of the European Society of Gynecological Oncology (ESGO 2015) was held from24th to 27th October. For the first time, an Awareness Run, to raise awareness of early detection of cervical cancer and HPV vaccination programs, was organized by the ESGO at this year's congress in Nice. The run activity's goal was to encourage a healthy life style, which directly affects gynecological cancer incidents. Over 250 delegates registered for the 5 km race. One of CEEGOG members, associate professor Jiří Sláma, finished the race in second place. Congratulations.